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Postgraduate Study

About the Cambridge Institute for Medical Research

The recent explosion of genomics has led to a rapid increase in data describing the genetic landscape of disease. There remains however a huge gap in translating those data into mechanistic understanding of how genetic changes actually cause human disease. Filling this gap will require understanding of both molecules and patients. CIMR's mission is to contribute to this effort by determining the molecular mechanisms of human disease in order to develop targeted therapeutic strategies.

Located within the Cambridge Biomedical Campus, CIMR's 24 research groups are led by a mixture of clinical and non-clinical Principal Investigators. World-leading expertise in protein structure and homeostasis, membrane trafficking and organelle biology is applied across infectious, immune, neurological and haematological diseases, with a particular interest in rare genetic disorders. In several cases, these efforts are leading to new treatments and diagnostics, with several spin-out companies and drug discovery programmes established.

Dedicated core facilities at CIMR include proteomics, microscopy, bioinformatics, flow cytometry and structural biology. The Institute is also committed to diversity and inclusion, with an emphasis on a positive research culture and impactful public engagement. Postgraduate training for non-clinical and clinical students is an important part of CIMR. Our 38 PhD and two MPhil students benefit from the supportive, collaborative environment of the Institute and from the wider School of Clinical Medicine.

3 courses offered in the Cambridge Institute for Medical Research

The Cambridge Institute for Medical Research (CIMR) is one of the leading research institutions in the UK. The Institute’s mission is to determine the molecular mechanisms of disease in order to advance human health, and the institute is founded on the principle of interdisciplinarity, leveraging extensive collaboration between basic and clinician scientists, outstanding core facilities and an inclusive, supportive working environment to tackle big problems.

CIMR’s ambitious Research Strategy is to generate a detailed understanding of cellular homeostasis across three main themes: protein folding and quality control, membrane trafficking and organelle biology. These pathways are fundamental to normal cellular function, so when they are altered by mutation they can lead to diseases that are rare, devastating, and frequently occur in the nervous system. Numerous infectious pathogens have also evolved to infect cells by exploiting and manipulating these pathways. CIMR, therefore, focuses on genetic and infectious disease areas where cellular homeostasis is altered, and which are frequently neglected and overlooked, meaning there is significant unmet patient need: rare genetic disease, neurological disease, and intracellular infection. There are 24 research groups working across these research themes at CIMR.

A one-year full-time MPhil programme of research is offered under the individual supervision of principal investigators based in CIMR. This course can also be taken as a part-time option over two years. During their MPhil, the students are based in a research group, supported by their primary supervisor and the CIMR Postgraduate Education Committee. There is no taught and examined coursework, but students are encouraged to attend research seminars at the Cambridge Biomedical Campus and elsewhere in the University, and postgraduate student seminars dealing with generic skills such as intellectual property rights, writing a thesis or paper, and entrepreneurship. Students write a thesis, which is examined via an oral examination.

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The Cambridge Institute for Medical Research (CIMR) is one of the leading research institutions in the UK. The Institute’s mission is to determine the molecular mechanisms of disease in order to advance human health, and the institute is founded on the principle of interdisciplinarity, leveraging extensive collaboration between basic and clinician scientists, outstanding core facilities and an inclusive, supportive working environment to tackle big problems.

CIMR’s ambitious Research Strategy is to generate a detailed understanding of cellular homeostasis across three main themes: protein folding and quality control, membrane trafficking and organelle biology. These pathways are fundamental to normal cellular function, so when they are altered by mutation they can lead to diseases that are rare, devastating, and frequently occur in the nervous system. Numerous infectious pathogens have also evolved to infect cells by exploiting and manipulating these pathways. CIMR therefore focuses on genetic and infectious disease areas where cellular homeostasis is altered, and which are frequently neglected and overlooked, meaning there is significant unmet patient need: rare genetic disease, neurological disease, and intracellular infection. There are 24 research groups working across these research themes at CIMR.

A three-year full-time PhD programme of research is offered under the individual supervision of principal investigators based in CIMR. This course can also be taken as a part-time option for over six years. The PhD students are based in a research group, supported by their primary supervisor, their postgraduate adviser, and the CIMR Postgraduate Education Committee. There is no taught and examined course work, but students can take part in core topic discussion sessions held once a week by PIs in CIMR.

Along with the specific research training provided in the laboratory in which the student works, he or she receives further training within the CIMR in the form of postgraduate workshops concentrating on research techniques, research seminars both on the Cambridge Biomedical Campus and elsewhere in the University, and postgraduate student seminars dealing with generic skills such as intellectual property rights, writing a thesis or paper, and entrepreneurship. Students write a thesis, which is examined via an oral examination.

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Biomedical science is currently undergoing a revolution, as the application of whole-genome sequencing technologies fundamentally change the way in which we understand the causes of both common and rare human disease. However, while sequencing is changing the speed and depth with which disease is diagnosed, it alone frequently does not lead directly to patient benefit. To develop new drugs and treatments, scientists need to develop sophisticated cellular models and understand pathological changes occurring within cells at molecular resolution. This combination of cellular, genetic and informatic tools is the next frontier of biomedicine, and one in which both academic and pharmaceutical industries are hiring rapidly.  

To equip students with skills to participate in this exciting new field, this program is designed to provide an exceptional postgraduate education in the molecular basis of human illnesses, their diagnosis, and potential treatment options. It combines taught content that spans diagnosis, cellular and molecular approaches and drug/diagnostic development with extensive hands-on research experience in cutting-edge research labs. 

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2 courses also advertised in the Cambridge Institute for Medical Research

From the School of the Biological Sciences

The Cambridge Biosciences DTP is a four year fully-funded PhD programme that aims to create highly skilled and employable people. The programme offers training across 23 University Departments/Institutes and 3 Partner Institutes providing access to a wide range of research areas related to the strategic themes of the BBSRC. We offer three types of DTP studentships:

  • DTP Standard
  • Targeted
  • iCase

During the programme, DTP Standard and Targeted students will undertake two ten-week rotations in different labs before commencing their PhD. They will receive training in a variety of areas including but not limited to statistics, programming, ethics, data analysis, scientific writing and public engagement. Students will also undertake a 12-week internship (PIPS).

iCase students are not required to undertake rotations but may do so if they feel that this training would be useful. They must undertake a placement with their Industrial Partner for a minimum of three months and a maximum of 18 months.

Students will be expected to submit their thesis at the end of the fourth year.

Part-time study, whilst not the norm, may be viable, depending on the project, and will be considered on a case by case basis so please discuss this option with your proposed supervisor before making an application for this mode of study.

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From the Faculty of Clinical Medicine

We provide high-quality research training to clinical health professionals with an aptitude for research to enable them to become future leaders in medical and healthcare science. We offer training in an outstanding environment, spanning basic science, translational medicine, interdisciplinary, behavioural and applied health research.

We take great pride in our track record of successfully training health professionals to undertake the highest quality research across Cambridge and Norwich. We offer one of the most rewarding environments in which you could pursue your research training with world-leading researchers in The  Schools of Clinical Medicine and Biological Sciences at the Universities of Cambridge, Wellcome Sanger Institute and other MRC, Wellcome & Cancer Research UK funded Institutes, Centres & Units in the wider Cambridge area, as well as the School of Health Sciences and Norwich Medical School at the University of East Anglia with other partners on the Norwich Research Park.  The most important criteria we are looking for are the pursuit of research excellence, hard work and the will to make a difference to health.

The programme faculty provides mentoring and guidance on opportunities to undertake pre-doctoral research placements, enabling successful candidates to make an informed choice of PhD project and supervisor.  Bespoke training and support for career development for fellows, together with support to supervisors, ensures a successful research experience.  Post-doctorally, we will guide fellows based on their individual progress, to make the transition into higher research fellowships and clinical pathways, enabling ongoing training with continuance of research momentum.

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Department Members


Professor Julian Rayner
Head of Department

  • 25 Academic Staff
  • 107 Postdoctoral Researchers
  • 45 Graduate Students

http://www.cimr.cam.ac.uk/

Research Areas